June 19

15.00 – 19.00    Registration, mounting of posters

19.00 – 19.15    Conference opening
Sergey Razin (Moscow, Russia), Chairman of the 25th Wilhelm Bernhard Workshop Organizing Committee

19.15 – 20.15    Opening Lecture
Yosef Gruenbaum (Jerusalem, Israel) Regulation of nuclear mechanics by the nuclear lamina

20.15 – 22.00    Welcome reception (restaurant, 1floor)

June 20

Workshop I Chromatin structure and dynamics (Part 1)
Chairmen: Gabor Szabo and Elena Gaginskaya

09.00 – 09.35  
Kerstin Bystricky (Toulouse, France) Transcription induced chromatin dynamics and reorganization at single gene loci

09.35 – 10.10  
Klaus Scherrer (Paris, France) 3D-Genome Organisation, Morphogenesis and Cancer

10.10 – 10.35  
Alla Krasikova (Saint-Petersburg, Russia) Three-dimensional genome architecture in chicken somatic and germ cells

10.35 – 11.00  
Ildikó Kristó (Szeged, Hungary) The actin binding cytoskeletal protein Moesin is involved in nuclear mRNA export
11.00 – 11.30  Coffee break
Workshop I Chromatin structure and dynamics (Part 1) - continuation
Chairmen: Alla Krasikova and Yana Musinova

11.30 – 11.55  
Alexander Ishov (Gainesville, USA) CENP-B protects centromere chromatin integrity by facilitating histone deposition via the H3.3-specific chaperone Daxx

11.55 – 12.20  
Christian Schöefer (Vienna, Austria) Visualizing chromatin architecture in nuclei and nucleoli

12.20 – 12.45  
Gabor Szabo (Debrecen, Hungary) The effect of histone modifications and DNA superhelicity on nucleosome stability

12.45 – 13.10  
Sergey Razin (Moscow, Russia) Organization and evolution of vertebrate globin gene domains
13.10 – 14.00  Lunch
14.00 – 15.00          Poster session I
Announcement of the best poster winners for the Poster session I
Workshop II Nuclear compartmentalization
Chairmen: Yosef Gruenbaum and Alexander Ishov

15.00 – 15.35
Ivan Raska (Prague, Czech Republic) Structure and dynamics of the Polycomb body

15.35 – 16.00
Masahiko Harata (Sendai, Japan) Roles of actin family proteins in the organization of functional structures within the nucleus

16.00 – 16.25
Elena Gaginskaya (Saint-Petersburg, Russia) The nucleolus in avian oogenesis

16.25 – 16.50
Veit Schubert (Gatersleben, Germany) Super-resolution microscopy reveals the ultrastructure of plant nuclei
16.50 – 17.20          Coffee break
Workshop III Nuclear envelope and lamina
Chairman: Ivan Raska and Yana Musinova

17.20 – 17.50
Ryszard Rzepecki (Wrocław, Poland) Analysis of protein complexes containing lamin B – interactions with topo II and with nucleic acids and chromatin in vivo.

17.50 – 18.15
Igor Sharakhov (Tomsk, Russia) Tissue-specific aspects of chromosome-nuclear envelope interactions
19.00  Sightseeing tour of Nizhny Novgorod
June 21
Workshop IV Chromatin Structure and dynamics (Part 2)
Chairmen: Kerstin Bystricky and Eugene Sheval

09.00 – 09.25
Veniamin Fishman (Novosibirsk, Russia) Targeted modification of topological domains in mice

09.25 – 09.50
Alexey Gavrilov (Moscow, Russia) Genome wide mapping of RNA-chromatin interactome in vivo

10.15 – 10.40
Yegor Vassetzky (Villejuif, France) Virus-induced nuclear architecture remodeling in human B-lymphocytes: a key factor in lymphomagenesis?

10.40 – 11.05
Tatyana Zykova (Novosibirsk, Russia) Polytene chromosomes – a portrait of functional organization of the Drosophila genome
11.05 -11.25    Coffee break
Workshop V Nuclear organization and transcription
Chairmen: Yegor Vassetzky and Nikolajs Sjakste

11.25 – 11.50
Pavel Hozak (Prague, Czech Republic) Nuclear phosphatidylinositol 4,5-bisphosphate islets contribute to efficient DNA transcription

11.50 – 12.15
Steven Kosak (Chicago, USA) Genetic polarity: the concomitant positioning of gene loci and the functional distribution of their encoded proteins

12.15 – 12.40
Paul Schedl (Princeton, USA) Drosophila dosage compensation: drawing connections between the chromatin entry sites (CES) for the MSL dosage compensation machinery and chromatin boundaries

12.40-12.50            Best poster presentation I
12.50-13.00            Best poster presentation I
13.00 – 14.00          Lunch
14.00 – 15.00         Poster session II
Announcement of the best poster winners for the Poster session II
Satellite meeting: Molecular and cellular events in human diseases
Chairmen: Marc Mirande and Olga Lavrik

15.00 – 15.20
Svetlana Dokudovskaya (Villejuif, France) Regulation of the mTORC1 pathway

15.20 – 15.40
Anna Smirnova (Novosibirsk, Russia) The study of activation effects of HIF transcription factor on the potential of endothelial angiogenic derivatives in human pluripotent stem cells

15.40. – 16.00        
Ekaterina Belousova (Novosibirsk, Russia) The new acceptors of PARP family proteins

16.00 – 16.20         
Iryna Tykhonkova (Kiev, Ukraine) Phospho-mTOR (Ser2481) associated with chromosomes during metaphase

16.20 – 16.50          Coffee break

Chairmen: Lev Ovchinnikov and Alexander Ishchenko

16.50 – 17.10         
Oleg Demidov (Dijon, France) A role of nuclear DDR-regulating phosphatase PP2Cdelta in modulation of tumor microenvironment and tumor resistance to chemotherapy

17.10 – 17.30         
Marc Mirande (Gif-sur-Yvette, France) Viral hijacking of translational components required for HIV-1 replication

17.30 – 17.50         
Bakhyt Matkarimov (Astana, Kazakhstan) Analysis of NCBI dbSNP big data

17.50 – 18.10
Elizaveta Alemasova (Novosibirsk, Russia) Production and purification of recombinant analog of Y-box binding protein
18.10 – 20.00          Meeting of the WBW International committee
18.10 – 20.00          Meeting of the GDRI committee.
June 22

Workshop VI DNA replication and repair
Chairmen: Sergey Razin and Olga Iarovaia

09.00 – 09.25
Olga Lavrik (Novosibirsk, Russia) Protein-protein interactions operating in base excision DNA repair

09.25 – 09.50
Nadezhda Rechkunova (Novosibirsk, Russia) Protein poly(ADP-ribosyl)ation by PARP1 as the regulating mechanism in nucleotide excision repair

09.50 – 10.15
Mikhail Klenov (Moscow, Russia) Role of piRNA system in transcriptional regulation of transposable elements and ribosomal RNA.

10.15 – 10.40
Alena Makarova (Moscow, Russia) The mechanism of the dRP-lyase activity of human DNA polymerase iota

10.40 – 11.10          Coffee break
11.10 – 11.35
Joao Matos (Zürich, Switzerland) A mechanism for controlled breakage of under-replicated chromosomes during mitosis

11.35 – 12.00
Alexander Ishchenko (Villejuif, France) Poly(ADP-ribose) polymerase 3 mono(ADPribosyl)ate DNA termini at double-strand DNA breaks

12.00 – 12.10          Best poster presentation II
12.10 – 12.20          Best poster presentation II

12.20 – 13.30           Lunch

Workshop VII Nuclear organization and disease
Chairmen: Pavel Hozak and Iryna Tykhonkova

13.30 – 14.15
WBW Young investigator award lecture Massimo Lopes (Zurich, Switzerland) Replication fork remodeling: a double-edged sword in genome stability and cancer therapy

14.15 – 14.40
Nick Barlev (Leicester, UK) Functional interaction between Lysine Methyltransferase Set7/9 and the RNA processing protein Sam68 controls its cellular localization and is required for p53 activity

14.40 – 15.05
Lev Ovchinnikov (Puschino, Russia) The Y-box binding protein 1 (YB-1) as a potential remedy for Alzheimer's disease

15.05 – 15.20
Diego Germini (Villejuif, France) HIV-1 protein Tat induces ROS production leading to genomic instability. A possible explanation to the B cell malignancies in AIDS patients

15.20 – 15.45
Nikolajs Sjakste (Riga, Latvia) Parameters of nitric oxide metabolism and DNA integrity in patients with autoimmune diseases
15.45 – 16.10
Ildikó Kristó (Szeged, Hungary) The actin binding cytoskeletal protein Moesin is involved in nuclear mRNA export
16.10                       Closure of the meeting - announcement of the venue for the WBW XXVI
18.00 - 22.00          Gala dinner on a boat*
*Please note that it would be impossible to leave the boat until 22:00, so please arrange your travel plans accordingly
June 23